The Hokey-Settings tab is shown open in the image below: Either action will bring up the configuration GUI below. You can modify them by pressing CTRL-5 or opening the tray menu while Portable-VirtualBox is running. Portable-VirtualBox makes default settings automatically. Portable-VirtualBox will extract the files it needs from the VirtualBox installer, and restart itself afterward if you select the last checkbox. If not, click 'Download The Installation Files of VirtualBox.' Portable-VirtualBox will show you the download's progress.
Go to the folder and run Portable-VirtualBox.exe.Download and run Portable-VirtualBox_v5.1.22-Starter_v6.4.10-Win_all.exe.Portable-VirtualBox is a free and open source software tool that lets you run any operating system from a usb stick without separate installation.